A tissue proteome specificity map that is actually good!

 

I am so excited by this great new resource!  

And not just because the most recent big paper purporting to do such a thing (this one - still out there and still misdirecting people!) was such a pile of garbage! 

In this new cell paper, this group did the work to FIND PROTEINS that legitimately appear to be organ specific! 

Don't want to read and just want a list of proteins that are -by protein - and by RNA - basically almost entirely produced by specific organs? Check out their nifty little portal! 

 Their RAW data is publicly available? What?!? What an amazing concept! They actually compare data from protein level and RNA measurements before claiming a protein in plasma originated in said organ? Amazing. For proteomic nerds - the organ data was acquired by DDA on a QE Plus running nanospray on 2 hour gradients. The plasma proteomics was done by DIA proteomics on a QE HF-X. High accuracy high precision measurements. I'll dig into it more soon, for sure, but it's absolutley worth checking out now.