And the winner for understated study so far for 2022 goes to.....
Man, this is why I'm still here doing this stuff, I guess. From the title and abstract alone, I bet you probably didn't want to read this. Why would you?
Well, you can get a program developed for this study from Github here that will allow you to operate your Q Exactive system with some new super powers!
MetaDrive? What's that do? Well, it's nothing to yell about really, it allows you to look at intact proteins on the fly and deconvolute them and then it selects multiple precursors for your intact protein (like targeted multiplex quantification) and will hit them with stepped CE allowing you to get massively more signal on your intact proteins. That's all.
When you do intact proteins on an Orbitrap and select an ion for fragmentation the best case scenario is that it looks like this and you selected that one charge state for your MS/MS fragmentation.