Param-Medic -- Automatic parameter optimization without database searching!

I'm honestly having trouble wrapping my brain around how this new free piece of software works -- and whether it would be an advantage over the tools I currently use for this, regardless it is an interesting read!

Somehow -- it can look at your RAW data and determine the mass accuracy settings that you ought to use for your database search, without looking at your database at all the way Preview or IMP Recalibration node does.

If you are using the Crux pipeline tools -- it has already been integrated as an option for you to check out. For the rest of us who don't want to use awesome free data processing pipelines from some guys in Seattle (what do they know about mass spec data processing anyway...), we he can download the stand-alone and run it in Python.