I'm gonna be conservative and say there are about 12 reasons to read this awesome new open access paper!
I'll name a few and see how far I get
1) A "how to" for clinical proteomics. 1 hour digestion? 45 minute runs? Now -- this is something practical for a clinical setting.
1.5) This had to move up the list. The samples were prepped with a robot liquid handler thing!
2) This section title "Plasma Protein Levels Are Individual-Specific" Holy cow! Why don't I have my own plasma proteome done yet?
3) XIC based label free quan (MaxQuant LFQ) applied to a clinical sized cohort (300+ patients; over 1200 runs!)
4) Beautiful downstream analysis -- that leads to clear biological conclusions on this cohort, including inflammation response, insulin resistance, etc.,
I really think I could get to 12, but I do have a job and I should probably not be late for it!
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