Edits 10/2/2025: Thanks for the emails and comments! It looks like this is only the first 1,700 files. Still fun to download and take a look at! Also, it looks like the newest O-Link Explort HT can do 300+ samples/instrument setup per day. That's faster than an Astral at 100SPD. My notes were on the previous O-Link Explore 30something which was 82 samples/plate. That's 82 samples prepared per work day/instrument set but I believe that takes 2 days. Even if it's just that is 410 samples/week compared to 700/week on the Astral. And WAY cheaper on the Astral.
WOOOOOOO! This paper is out and could represent a full paradigm shift in how we do plasma proteomics!
Thousands and thousands of plasma samples! Done just about as fast as you could do it with O-Link and WAY WAY WAY WAY faster than you could do it with Illumina Protein Prep. (40,000 samples in this study, not counting QCs, were completed on one instrument in less than 1 year). This would take just over 4 years with Illumina's new and non-quantitative protein detection technology. One instrument running O-Link explore would take longer than this study, but not by a lot.
Here are my notes from the preprint!
AND all the data is linked in the paper that you might have found very extremely disappointing when it wasn't available in the preprint!
Note 2 astrals were used at 100 SPD. I think OLink would be faster - I thought it's 2000 samples per week per instrument?
ReplyDeleteReading through the paper, I realized that while they already have analyzed 40,000 plasma samples from 50,000 samples study, in this publication they "only" look at the 1705 interspersed QC plasma samples measured so far. The really large data will be published later in a separate publication.
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