Holy shit, y'all.... if you're going to read 1 proteomics paper in 2024. This should be that paper.
I'm going to change the formatting of the blog to add a "success stories for proteomics technology" or something over there -->
I haven't before because .....it's not a very long list..... THIS IS ONE.
1) Let's start with one of the most horrific diseases you've never heard of. TEN or Toxic epidermal necrolysis. It's as bad as that last word suggests. Patients are on other treatments - it looks like typically from chemotherapies, but possibly also from other treatments - AND 30% or more of their skin dies and falls off. Mortality rates are high. Skin is an important thing for humans to have all of.
2) Screw the method and approach and the fact that a TIMSTOF SCP and an Orbitrap Astral were used in combination with multiple really good spatial techniques. All cool stuff -
THEY IDENTIFIED A MECHANISM - something we already have approved drugs in the clinic for - and it was something we already had drugs for in the clinic -
AND THEY CURED PEOPLE! 10 patients?!? I was excitedly reading this on my phone while my kid was digging a hole outside and I'm only getting to type this while he's in the bath.
All the stuff in the middle is important. They did the deep visual proteomics workflow with the TIMSTOF SCP. They derived cells for deep proteomics/phosphoproteomics from limited material with the Astral. What they found in both the FFPE tissues they were analyzing and multiple relevant models was that the disease messes with JAK/STAT. JAK inhibitors cured mice - and then - they worked on people!
Such an inspirational, exciting and beautiful study.....
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