The best figure in the paper is probably the panel at the top. Go to 1,000 files and - yeah - you use a lot of cores but you cut 6 days of processing time to a few hours. Since Clouds (which are just someone elses HPC) tend to do a really good job in charging you for what resources you actually use (because it's a highly competitive commercial environment and if they didn't do it right you'd give your money to someone else) the costs end up working out to just about the same, same cost but you get your results back almost a week later? Everyone is taking that deal.
Again, very preliminary, but you should be excited because you know someone who would like to talk to you about their 5,000 FFPE blocks for proteomics and you can only avoid them for so long. Pretty cool to know that someone is thinking about a bottleneck you haven't go to yet!
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