Friday, February 9, 2024 about 1.4min plasma proteomics?


LCMS based proteomics isn't a "high throughput" technology, right? I mean, you hear it all the time. I sure as hell hear it ALLLLLLLLLLLLL the time here in Genome Alley. "If you get the $20M transcriptomics platform and you load 1,000 library preps on it, it'll knock it out IN A DAY."

In that same amount of could also knock out a pretty impressive depth of 1,000 human plasma samples...

I think this guy from Annapolis is over-reacting. This isn't the first time we've seen some crazy numbers out of flow injection proteomics from this PI. He's been messing around with this stuff since he was in Wisconsin, but with ever increasing numbers.

But on plasma? With the 10-order of magnitude concentration range? This is big time. FAIMS was used here, but - FAIMS is great, but it's got a resolution of approximately 10. For that reason...use FAIMS, don't use FAIMS, it's not that big of a difference for most things, right? Running a 2.8 minute injection on this setup would give you about a resolution of 2, right? 

These nanoparticles might need a serious investigation. Super cool study all around! 

1 comment:

  1. Looks pretty much like Seer‘s Proteograph technology. With their newest XT technology they even went down to 2 NPs.