I think the preprint of this paper might have made the blog a while back, but even if it did (or some iteration -- preprints do often evolve) it's worth revisiting. And...if I read it and meant to write something and forgot? Even better!
How far can you reeeeeeeeeeeeeeeeeeeeeeaaaaaaaaaaaaaaaaaaaaaallly push a Q Exactive "Classic" system if you pulled out the stops?
Really really really optimized your DIA windows?
You used some fancy micropillar chromatography for long gradient single shot?
You used even fancier predicted libraries?
Could your "Classic" system come back with 8,000 protein confident protein IDs in a single run? You'll have to read it to find out, I guess.