I've only got a few minutes, but -- wow -- is this ever worth reading!
Microbial ID by shotgun proteomics is NOT new. But promising study after promising study seems to end up with -- no new clinical assays.
MALDI-TOF with a BioTyper is easier in the clinic, I guess, but maybe we just need the right technologies to get us over the hump. Clearly, the insistence of researchers to continue utilizing NanoLC is a big hurdle, but maybe innovative sample prep methods would also help bridge the gap?
They use some crazy technology in this one. A flow cell digestion method that allows a tryptic digest of bacterial proteins in one hour? And a depletion technology that removes "host" (human!) biomass??
I have to mention that this study is a big collaboration between groups in Stockholm (where HUPO 2020 is!) and Gothenburg, a city blessed by some dark metal gods or something to be the birthplace of the greatest bands that have ever walked this earth. Yup, I definitely had to mention that.
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