Disclaimers! I've had this open on my desktop since I got back from vacation and I do not get it. We're way way out of my wheelhouse.
I do think it's worth posting here, though, for people to think about, if only so I can close the tab and reference it here later.
Ultimately, I don't think it has any real overlap with what most of us do PTM-wise with mass spectrometrs. We're looking at how all the acetylation sites (for example) change in appearance and abundance when we put drug A into some cells when compared to control cells.
However, the interest here has to exist here in being able to drive the PTM engineering using in vitro systems. The proof of concept leads to the discovery of mutations that drive up the concentration of the products they want. (Confirmed by targeted LCMS/MS) Still really cool (I think).
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