Man, this is so freaking smart and inciteful - and comes with suggestions for how to fix it!
Now, the rumor is that the reviewers put them through the ringer on this to make them prove this wasn't something isolated to wherever the heck Heidelberg is. So they extracted data from files in ProteomeXchange from other locations and since the Bruker crazy .sqlite database format keeps information on freaking everything - they could pull weather reports and show the same stuff happens in Boston.
Totally worth keeping in mind, because if you're doing something like the last paper on the blog where you do little tiny 1/k0 isolation windows - but...those...change....cause your air pressure drops.... that little window isn't too great all of a sudden. If you're running the "long gradient default methods" where you're scanning from 0.6 - 1.6 it probably doesn't make a difference, you're already fragmenting tons of dumb shit anyway (like PTMs and short peptides and long ones) that you won't identify. Super duper smart paper.
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