I have a single imaging file from our TIMSTOF Flex that contains 100,000,000 spectra. 100 MILLION spectra. Try doing a lot of stuff with that! THEN think that is just one of the control tissue slices. You've got 4 more of those + 5 drug treated. It makes my complaints about the LCMS data file sizes seem a little stupid.
TIMSCOVERT to the rescue??