I know this is kinda old, but I had a great experience with crowd sourcing research recently and I realized I've never talked about FoldIt. If you aren't familiar, this is a great (and crazy difficult) puzzle game where you solve protein folding problems. FoldIt players have contributed to solving a slew of biological problems and were a feature in Nature a few years back as described in this Nature article here.
If you are interested and better at puzzles than me, you should check out FoldIt here. There is a new version out this month for Apple, Linux, and Windows.
Oh, and here is a great introductory video.
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