Currently in press at MCP: the paper in the title of this post from Heather M. Syred et al., at the University of Edinburgh.
This paper is interesting for a number of reasons, not limited to the following short list:
1) Microtubules are WAY more important than we tend to think that they are
2) They are far more regulated than we tend to think they are
3) The first 2 points illustrate how little we actually know about how cells work, because these things are hugely expressed in most cell types
4) A reasonably simple method is defined in this paper for obtaining high-purity microtubules (and cytoskeletal proteins in general!) that really opens this kind of method to researchers who are very interested in cells where these structural proteins play a key roll (epithelial-mesenchymal transition, anyone?)
5) Whoever did the fluorescent microscopy did a top notch job. My favorite way to end a paper is with IHC/ICC and this work is just stunning (and better than anything I've done!)
If you're interested in MAP kinases, cytoskeletal rearrangements, mitosis or in cell biology in general, I recommend you check this one out.
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