Monday, April 1, 2013
Heavy chemistry -- MS/MS fragmentation pathways that lead to erroneous phosphosite assignments
This month's Proteomics (Wiley) has another interesting paper on jumping phosphorylation site assignments. The article is from Li Ciu and Gavin Reid at Michigan State University. The focus is on using some detailing ion trap CID fragmentation pathways and how these pathways correlate with mistaken phospho-site assignments. I am so glad that there are chemists out there who do these types of studies. Every new insight into what these instruments are doing internally ultimately helps us understand the biology side of things.