An elegant way to sample peptides and intact proteins from important stuff!

Oh shit. That's a snake in the picture! 

Okay, so maybe this'll sound obvious, but it only seemed obvious to me after I skimmed this new paper. 

What if you just wanted to sample out the endogenous peptides before you did your intact protein stuff - or digestion for shotgun proteomics? 

They stage tipped out of the solution to enrich the small peptides, and then precipitated all the big stuff to do the rest. It's probably a solid assumption that most of the big proteins won't either go into the little stage tip, and the ones that do won't elute out under the same conditions that the endogenous peptides will! 

Smart, right? And then they can do all the venomomics!