If you've also wondered where a ZenoTOF 7600 would stack up against your hardware when running comparable flowrates (cause you're probably running nanoLC). This new preprint did the heavy lifting for you.
Probably formerly counterintuitive, but something we're all getting used to now - a super fast TOF tends to get more IDs at faster gradients. Narrow those peaks to concentrate that signal and they perform better. As the concentration goes up, that effect tends to level out.
Based on some vendor marketing material you might be quick to disparage these numbers, but I think we all know that our own labs aren't the perfect operating environment of vendor facilities and after full time use running weird stuff in our instruments they don't run the same at install.
What is interesting to me is that - yes - NanoLC seems to help, but it doesn't really help that much (maybe 10-20%?) and I really enjoyed the ease of use of the Microflow setup on my ZenoTOF before a ceiling waterfall at Johns Hopkins destroyed the shiny thing. It should probably also be pointed out that this is now a 2 generations old ZenoTOF, as the 7600+ and the 8600 are improved versions of this hardware. Still, a really visually appealing study that answers a lot of questions that I (and maybe you?) had about this instrument.
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