I'm leaving this here largely for me to check if I can find plasma proteomics by LCMS that I can confidently link back to this same cohort. There is a lot of LCMS proteomics data from these authors, though all I have actively worked with has been muscle biopsies.
However - people are going to want to use the 11k SomaScan assay that is now out there, and it is nice to see that these authors find - after proper normalization and a lot of batch effect analysis - that data from these two technologies are aligned.
It should be noted that the precision of SomaScan has been shown to be solid. In 8 years of watching for it, I still haven't seen any evidence that the system produces results that are an accurate reflection of the amount of protein present.
With the growth of this technology - including the use by some of the best groups in the world, such as this one - I hope hope hope hope that it is actually accurate and one day we'll see proof of it.
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