Monday, May 13, 2013
Xenografts induce liver dysfunction in mice
In a step away from proteomics over to metabolomics, this is a pretty interesting story in press at MCP. The paper from Fei Li et al., takes a look at the urine metabolomics of our favorite cancer models, mice that are growing xenografted tumors. We all know this system is a flawed one, but it is absolutely the best thing out there. There are tons of examples where treating a series of mice with these tumors with different combinations of drugs has told us exactly how to eradicate a specific tumor. A variable that no one has evaluated (as far as I know, anyway) how the growing tumors affect the liver function. Obviously implanting a tumor is a pretty bad thing, but here are quantifiable changes. I highly recommend this paper for you metabolomics people as well as anyone working with xenograft models!