This impressive new study comes from David Graham's lab at Johns Hopkins. After HIV infects a cell it releases new particles to infect other cells. Like many diseases, HIV appears to evade the immune system by taking hiding itself in the host proteins.
The Graham lab captured post-infection HIV particles and identified 25 human proteins that appear to be essential to the HIV infection. These 25 were targeted because they were conserved in very different HIV infection models.
You can read the Hopkins press release here (along with a nice video by Dr. Graham). The original paper in JPR is available here.