Ummmmm......okay so....these specs are amazing....
How do you increase mass resolution? Generally just increase the flight path, right? But you can only go so far before there isn't enough electricity on earth to generate the appropriate vacuum. Reflectrons double the path and the W-TOFs from Pegasus that a big vendor acquired recently can really push those numbers up by multiple reflectrons.
The Y-TOF takes that concept to 11. It's one thing to say "I can make my instrument do 1 million resolution". Give me 45 minutes with your Q-Exactive and I can make it do 1 million resolution. Each scan will take about 8 minutes. (more like 4 seconds, I forget) but it's completely impractical.
AND you can tune a Time of Flight to get really good mass resolving power at one particular m/z. My Q-TOF gets incredible resolving power in a mass range that isn't exactly where I need it.
The Y-TOF did a 30 minute proteomics run and averaged 600,000 to 800,000 resolution across the usable peptide range!!!
AND sub-PPM mass accuracy. Parts per BILLION mass accuracy. ON A TOF.
Obviously a prototype, but more obviously something we should keep our eyes on. Worth noting, they do have to use Astral level loads for bulk proteomics (1 microgram of peptides for the best data) and that this prototype isn't going to smoke your recently purchased $1M instrument, but it's starting in a very nice spot.
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