tag:blogger.com,1999:blog-3693238014525650573.post2869340696812776888..comments2024-03-19T00:20:07.007-07:00Comments on News in Proteomics Research: How far is the human proteome project at this point?Unknownnoreply@blogger.comBlogger2125tag:blogger.com,1999:blog-3693238014525650573.post-82935482989256849972013-12-02T13:18:35.132-08:002013-12-02T13:18:35.132-08:00Agreed, post-translational modifications, along wi...Agreed, post-translational modifications, along with alternative RNA splicings, mean that any of the approximately 20,000 predicted protein coding genes can produce tens, hundreds, or thousands of distinct protein molecules. So finding MS/MS evidence for 62% of the predicted human protein coding genes is indeed just the tip of the very large iceberg that is the <a href="http://www.hupo.org/initiatives/" rel="nofollow">Human Proteome Project</a>. The project also aims to determine which protein molecules are made in which tissues, at which stages of development, and under which conditions. I haven't met any protein scientist who is underestimating the complexity of this undertaking. However, you make a very good point: we don't want funding agencies to conclude from our 62% that the entire project is 62% complete. It is far from complete when one considers PTMSs, and some facets of the project have barely begun. At the same time, it is a good thing to identify a portion of the project that is quite tractable and with which we can make measurable and satisfying progress.Terryhttps://www.blogger.com/profile/12070629430943302376noreply@blogger.comtag:blogger.com,1999:blog-3693238014525650573.post-76230931813942153602013-12-02T00:29:18.861-08:002013-12-02T00:29:18.861-08:00This resource from B. Kuster in Germany has (an im...This resource from B. Kuster in Germany has (an impressive) 93% coverage of the Human Proteome. Their strategy, to re-analyze high-quality published MS data:<br />https://www.proteomicsdb.org/<br /><br />Javihttps://www.blogger.com/profile/07702620733999321691noreply@blogger.com