Saturday, March 9, 2019

Better chromatography for crosslinking!!


Okay! This is more of what proteomics needs!  More sophisticated and better chromatography needs to sneak in here and there and this great note is a perfect example of why.



My heart sank when I realized a lot of people were breaking out the SCX columns to enrich for their crosslinked peptide species. I'm sure SCX still has uses out there in the world, but when I hear those letters all I think of is putting in milligrams of peptides and getting micrograms back, so maybe this is the answer?

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