Monday, June 11, 2018
Tired of trying to find your PARPs? Cleave 'em off!
Do people still look for PARP inhibitors? I haven't heard of any in a while.
PARP is obnoxious because it's a polymer PTM. (This is a good review on it.) Unlike more friendly PTMs like ubiquitin, there isn't a friendly cleavage site coupled with a nice mass shift.
This new note at JPR shows a great way to get to the proteins that are PARP'ed (PARPyPARPylated?) by getting down to the proteins and knocking it off.
Much better idea!
Edit: I didn't try hard on the nomenclature at all. This link at Ribon pharmaceuticals explains the different types of these things.