Friday, April 27, 2018
Mango -- Clean up chimeric spectra for crosslinking experiments!
Yes there are around 40 different software packages for crosslinking analysis. And some of them actually work!
However -- Mango (JPR paper here) looks like it meets a specific and important need -- cleaning up the chimeric (multi peptide) spectra for processing!
You know the way that ETD totally doesn't look like it worked unless you clean up the data? I think Mango is going to allow us to look at crosslinked MS/MS spectra that we couldn't extract anything from before -- and provide us with all sorts of new information.