Yes there are around 40 different software packages for crosslinking analysis. And some of them actually work!
However -- Mango (JPR paper here) looks like it meets a specific and important need -- cleaning up the chimeric (multi peptide) spectra for processing!
You know the way that ETD totally doesn't look like it worked unless you clean up the data? I think Mango is going to allow us to look at crosslinked MS/MS spectra that we couldn't extract anything from before -- and provide us with all sorts of new information.
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