Thursday, March 22, 2018
BenchSci -- Find antibodies based on published proof that they work!
Antibodies aren't going to go away, but maybe this cool new site can alleviate one of the biggest headaches -- finding one that has been proven to work for your application.
1) Going to a manufacturer website X
2) Seeing if they have an antibody for your protein
3) Checking if that antibody works for immunoprecipitation or whatever
4) Checking if the manufacturer just says it does -- or if anyone has actually published anything on it
5) Checking the paper to see if you believe the author's results...
6) ...sigh.... go back to 1 (rarely, of course! it got through peer review, didn't it?!? I'm just being funny, but still, that's a lot of clicking through webpages!)
This team uses a machine learning algorithm thing to scroll through the literature and find published proof that there are antibodies for a protein and that they work for certain applications
I talked to one of the developers to:
1) Make sure that this is really what they are doing
2) Make sure that they'd considered scientific literature access stuff because this sounds like a great idea -- as long as they don't end up going to prison for it next week. They are actually working with individual publishers so this is all legit.
3) To suggest they contact all the proteomics journals next(!! and they are !!) so their database can have more MS-compatible antibodies.
To use it you put in your protein of interest in the search bar at the top and on the right blue bar you can start adding filtering parameters like what organism, cell type, application, etc., This will start to reduce the figures that show proof of the antibody working for your application.
TADAA! You've got the direct link to the peer reviewed evidence of a functional antibody -- then you know what company to go to.
It looks like you need to register for a free account to get some of the info, but as far as I can tell that's the only catch. (Leave me a comment if you find other ones, please.) Right now it looks like all wins -- You get to the right reagent faster and you have your reference for why you selected that antibody in the first place!