or Byonic it, but try streaming NBA games when your resource monitor has looked something like this since Friday....
What was I talking about? Oh yeah!
It is a whole lot easier when the FASTA contains your peptide sequence! And if you're studying something like cancer, chances are the normal database resources don't have what you're looking for.
You'll find a couple of enthusiastic posts on this dumb blog about the XMAn cancer mutation database that Virginia Tech researchers assemble and maintain (Go Hokies!)
CanProVar is another sweet resource out of Vanderbilt that is built from public repositories and dbSNP files (whatever those are).
Which one should you use?
A first comparison between the files is that CanProVar is smaller than XMAn, which would vastly improve the search time on big datasets. The downside, of course, is that the database is...smaller.... which probably means fewer mutations are present.
You can check out CanProVar here.
Apparently, it predates other resources by quite a bit, cause here is a paper on it from 2010. Somehow, I've either never seen it before -- or I've forgotten it. And this is exactly why Twitter is awesome for science!