Friday, October 7, 2016
Cool summary of p53 structure/function!
p53 is a super important protein in cancer. Close to half of the tumors identified in the U.S. each year have at least one p53 mutation. p53 is also a pain for proteomics because, under normal (and some of the mutant conditions) its cleaved up by another regulatory protein so rapidly that we'll often not see even a single peptide from the protein in a global analysis.
This summary in Science talks about some of the hurdles the drug development people (trying to restore messed up p53) have to go through and is a solid summary of the protein, what it is and how it works. As a free bonus you totally find out 1) that elephants don't get cancer and 2) why!