Tuesday, June 7, 2016
When you get to only 1 talk on a day at ASMS? Top-down KRAS, FTW!!
Top-down proteomics + K-RAS (the most common protein mutated in cancer!!) Yup, that's where I'm going to end up.
This talk was an extension of this recent paper I rambled on about recently.
Thinking "Great....another talk on a paper I can read?" Since reporting on the K-RAS intact proteomics data, they report 10x more coverage of intact proteins. They also show the improvements in top-down technology allows identification of positional isoforms (which all come out in one single peak!) and improved statistics that lead to all of these new proteins.
They get enough quantifiable top-down that they can do pathway analysis!! Quick conversation with the presenter says this paper is in works! I sure can't wait for it!