I've been asked this question a couple of times. And maybe now I know the answer.
At first run, it certainly looks like PD 2.1 installs just fine with nothing special whatsoever on Windows 10.
Now...that being said, this isn't officially supported by the vendor. And just because the couple HeLa runs I just did seem to go just fine doesn't mean that every feature will be ready...but, again, I haven't had a problem yet!